The Histochemistry of Chronically Sun-Damaged Skin
نویسندگان
چکیده
منابع مشابه
Surgical management of melanoma in situ on chronically sun-damaged skin.
BACKGROUND Lentigo maligna (LM) commonly presents as a slow-growing pigmented macular lesion in chronically sun-damaged skin and may progress to invasive melanoma. Many regard it as a subtype of melanoma in situ (MIS), and surgical excision remains the preferred treatment, but standard 5-mm surgical margins recommended for typical MIS are often insufficient for LM due to its indistinct borders ...
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Fructoaldolase activity in primate skin and appendages has been assayed with a highly sensitive fluorometric method. Epidermal fructoaldolase has characteristics similar to the fructoaldolases obtained from animal sources. The fructoaldolase activities of various skin structures are remarkably high; all glandular structures (except for apocrine sweat glands which have the highest activity of 24...
متن کاملSafety and efficacy of dose-intensive oral vitamin A in subjects with sun-damaged skin.
PURPOSE Previously, we reported the results of a Phase III, placebo-controlled trial in 2297 randomized participants with moderately severe actinic keratoses wherein 25000 IU/day vitamin A caused a 32% risk reduction in squamous cell skin cancers. We hypothesized that dose escalation of vitamin A to 50000 or 75000 IU/day would be both safe and more efficacious in skin cancer chemoprevention. ...
متن کاملNuclear morphometry and molecular biomarkers of actinic keratosis, sun-damaged, and nonexposed skin.
Computer-assisted image analysis is useful for quantifying the histologic and molecular changes of sun-induced squamous cell carcinoma progression. We used the CAS 200 image analysis system to measure nuclear morphometric parameters, p53 expression, and proliferation markers in actinic keratosis (AK), sun-exposed, and normal skin in 51 patients. Nuclear morphometry revealed significant increase...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1961
ISSN: 0022-202X
DOI: 10.1038/jid.1961.141